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Risankizumab의 치료 효과 소실 후 deucravacitinib 전환으 로 호전을 보인 중증 판상 건선 증례

Tue, 31 Dec 2024 15:00:00 GMT

Title: Risankizumab의 치료 효과 소실 후 deucravacitinib 전환으 로 호전을 보인 중증 판상 건선 증례 Author(s): Jin Woong Jung; Young-Wook Ryoo; Sung Ae Kim Abstract: We report a case of severe plaque psoriasis in a 49-year-old woman with schizophrenia and depression, who had suffered from widespread pruritic psoriatic plaques for over 20 years. The patient had a habitual tendency to rub and scratch the lesions, which aggravated the disease. She initially showed a complete response (Psoriasis Area and Severity Index, PASI 0) to risankizumab, an IL-23p19 monoclonal antibody. However, three years later, she experienced secondary failure characterized by rapid lesion recurrence and severe pruritus. As the underlying cause of treatment failure was unclear, therapy was switched to deucravacitinib, a selective oral TYK2 inhibitor. Within two months, the patient exhibited significant clinical improvement, with near-complete clearance of plaques and relief of pruritus. This case highlights the potential of TYK2 inhibition as an effective alternative in patients who experience secondary loss of efficacy with IL-23 inhibitors.

Knowledge and the behavioral patterns of photoprotection among Koreans with skin disease

Sun, 31 Dec 2023 15:00:00 GMT

Title: Knowledge and the behavioral patterns of photoprotection among Koreans with skin disease Author(s): Seong Jin Jo; Seong Rae Kim; Si Hyung Lee; Young-Joon Seo; Hyo Hyun Ahn; Jong Hee Lee; Sang Ho Oh; Ki-Heon Jeong; Kui Young Park; Chul Hwan Bang; Min-Soo Kim; Jae Yoon Jung; Young Wook Ryoo; Sang Seok Kim; Dae Hun Suh Abstract: Background: Photoprotection is crucial in preventing the development and progression of various skin diseases. However, patients with skin disease have limited awareness of photoprotection. We evaluated the knowledge and behavioral patterns of photoprotection among Koreans with skin diseases. Methods: A cross-sectional study was conducted in 11 general hospitals across South Korea. The study population consisted of patients aged 19 years or older who visited dermatologic clinics for their skin diseases. A self-administered questionnaire was used to collect patient demographics, knowledge of photoprotection, and photoprotective habits. Results: In this study, 1173 patients with skin cancer, hyperpigmentary disorders, hypopigmentary disorders, or other skin diseases participated. Females scored significantly higher in knowledge of photoprotection compared to males (mean score 8.4 vs. 7.8; p < .001), and younger patients (<50 years) scored higher than older patients (mean score 8.7 vs. 7.5; p < .001). Males also reported longer sun exposure times and lower usage of photoprotective measures (both p < .001). Patients with skin cancer had the lowest mean knowledge score (7.1 ± 2.6) and were less likely to use photoprotective measures compared to other groups (p < .001). In contrast, patients with hyperpigmentation actively avoided sun exposure compared with other groups (p < 0.001). Conclusions: Knowledge of photoprotection among Korean patients with skin diseases varied depending on the gender, age, and type of skin disease. Their photoprotective behaviors were inadequate, especially among males and those with skin cancer. These findings emphasize the importance of educating and tailoring photoprotection strategies for patients with skin diseases.

In Memory of Professor Joon Young Song

Sat, 31 Dec 2022 15:00:00 GMT

Title: In Memory of Professor Joon Young Song Author(s): Sung-Ae Kim; Myung Jin Lee; Young Wook Ryoo Abstract: Professor Joon Young Song was a dermatologist who exhibited extraordinary dedication to medical education in the Daegu-Gyeongbuk region. After graduating from Kyungpook National University School of Medicine in 1958, he obtained his dermatology specialist certification in 1962. From 1966 onwards, Professor Joon Young Song guided future generations at Keimyung University Dongsan Hospital for 33 years. He also conducted research in mycology and leprology and, notably, dedicated his life to treating patients with leprosy in the Daegu-Gyeongbuk region. Professor Joon Young Song contributed to the development of mycology and leprology in Korea, following the footsteps of Professor Soon Bong Suh in the Daegu-Gyeongbuk region.

손발톱 건선

Sat, 31 Dec 2022 15:00:00 GMT

Title: 손발톱 건선 Author(s): Yura Kim; Sung-Ae Kim Abstract: Chronic plaque psoriasis is the common disease of inflammatory nail disease. Ninety % of psoriasis patients experience nail symptom during the lifetime. Nail psoriasis is strongly associated with severe cutaneous psoriasis and psoriasis arthritis. Nail psoriasis patients experience pain, dysfunction, and social stigma and are subject to significant restrictions on their daily activities and quality of life. Psoriatic nail involving matrix can cause pitting, leukonychia, red spots in lunula, and nail plate crumbling, while nail bed involvement can result in onycholysis, “oil drop” discoloration, nail bed hyperkeratosis, and splinter hemorrhages. Evaluating the severity of nail disease can be challenging even in clinical practice. Although the nail psoriasis severity index (NAPSI) is widely used in clinical practice, it is time consuming and rarely used in clinical practice, so it is necessary to develop a simplified disease severity score for nail psoriasis. Treatment of nail psoriasis differs depending on the number of involved nails, the affected site of nail and presence of skin and/or joint involvement. Patients with mild nail psoriasis can be treated by topical therapy, and systemic treatment including biologic agents can be performed for severe nail psoriasis. Here, we aim to review the characteristics of nail psoriasis and provide an updated up-to-date review of the management and treatment options currently available for nail psoriasis.