근이영양증 근세포의 미세형태학적 변화

Other Titles
Ultrastructural Changes of Muscular Dystrophy
Authors
김덕영손태중
Department
Dept. of Plastic Surgery (성형외과학)
Issue Date
1985
Citation
Keimyung Medical Journal, Vol.4(2) : 143-150, 1985
Abstract
The author studied two cases of Duchenne type of muscular dystrophy by light and electron microscope to examine the morphologic interpretation about morphologic change and pathogenesis of them. The results obtained were as follow: Light microscopically,decrease of muscle fibers, increase of connective tissue, irregularity and rarefaction of muscle of muscle fibers, hyaline degeneration were observed. Histologic findings were markedly variable from nearly normal to markedly affected foci showing severe destruction of muscle fibers and muscle fibers and stromal fatty infiltration. Electron microscopically, there were focal loss of myofibrils around Z-line which is replaced by mitochondria, dilated SR and lipid droplets on the minimally affected foci. But severely affected portion shows widespread fragmentation of muscle fibers and focal rarefaction of muscle fibers. Rarefaction was especially prominent just beneath sarcolemma. Rarefacted area which composed of granular substance and degenerated membranous tissue was especially prominent just beneath sarcolemma. Considering the variable rarefaction of muscle fibers which is more prominent beneath degenerated sarcolemma, degeneration of sarcolemma was supposed to be involved on the pathogenesis of muscular dystrophy. And it is reasonable to interpret clinical findings of various muscular dystrophy according to the theory about degeiieration of sarcolemma. But this study is indirect one and requires further studies about abnomalities of sarcolemma by direct method.
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14388
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Plastic Surgery (성형외과학)
2. Keimyung Medical Journal (계명의대 학술지) > 1985
Keimyung Author(s)
김덕영
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