Keimyung Medical Journal, Vol.7(1) : 128-135, 1988
Toxemia is the first one of three main causes of maternal mortality in Korea, but the pathogenesis is uncertain. Toxemia involves multiple organs and mianifests various clinical symptoms including abnormal liver function test. Although it is transient and disappears after delivery, the clinician always should be aware of it. We analyzed 997 cases of toxemia in 19537 obstetric charts of pregnant women admitted in the department of obstetrics & gynecology, Dongsan medical Center in a period of ten years from January 1977 to December 1986. The result were as follows: 1) The incidences of abnormal liver profile in toxemia were 5.4% of bilirubin, 82.9% cholesterol, 56.6% total protein, 86.4% albumin, 13.9% globulin, 91.9% ALP, 23.3% AST, and 9.4% ALT. 2) Satistical significance between abnormal liver profile and gestational age was observed in total protein, albumin, ALP, and AST(p<0.005). 3) Toxemia compared with abnormal liver profile of nontoxemia group showed statistical significance in all items of liver profile(p<0.005). In conclusion, toxemia result in abnormal liver function test, especially abnormal total protein and AST value in abnormal gestational age.