Hepatitis B Core Antigen의 간세포내 분포 양상에 대한 연구

Other Titles
Cytoplasmic localization of hepatitis B core antigen in hepatitis B virus infected livers
Authors
이상숙장은숙정재홍
Department
Dept. of Pathology (병리학)
Issue Date
1989
Citation
Keimyung Medical Journal, Vol.8(1) : 97-103, 1989
Abstract
Routine use of commercially available antisera against hepatitis B core antigen(HBcAg) obtained from Escherichia coli transfected with HBV-DNA, has permitted a re-evaluation of the histochemical distribution of the hepatitis B core antigen in liver tissue. HBcAg, classically described almost exclusively in the nucleus, was found with a high frequency in the cytoplasm of liver cells. Our data indicates, however, that formalin fixation and paraffin embedding destroy most of HBcAg antigenicity. With protease digestion, most of the masked HBcAg antigenicity could be recovered. HBcAg was found in 41/58(70.7%) of HBsAg/HBeAg positive subjects, and in 13/16(82.3%) of HBsAg/anti-HBe positive subjects; in both groups the cytoplasmic expression including nuclear/cytoplasmic localization of the antigen was predominant(94.4%).
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14565
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
2. Keimyung Medical Journal (계명의대 학술지) > 1989
Keimyung Author(s)
이상숙; 장은숙; 정재홍
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