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Hepatitis B Core Antigen의 간세포내 분포 양상에 대한 연구

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Affiliated Author(s)
이상숙장은숙정재홍
Alternative Author(s)
Lee, Sang SookChang, Eun SookChung, Chai Hong
Journal Title
Keimyung Medical Journal
Issued Date
1989
Abstract
Routine use of commercially available antisera against hepatitis B core antigen(HBcAg) obtained from Escherichia coli transfected with HBV-DNA, has permitted a re-evaluation of the histochemical distribution of the hepatitis B core antigen in liver tissue. HBcAg, classically described almost exclusively in the nucleus, was found with a high frequency in the cytoplasm of liver cells. Our data indicates, however, that formalin fixation and paraffin embedding destroy most of HBcAg antigenicity. With protease digestion, most of the masked HBcAg antigenicity could be recovered. HBcAg was found in 41/58(70.7%) of HBsAg/HBeAg positive subjects, and in 13/16(82.3%) of HBsAg/anti-HBe positive subjects; in both groups the cytoplasmic expression including nuclear/cytoplasmic localization of the antigen was predominant(94.4%).
Alternative Title
Cytoplasmic localization of hepatitis B core antigen in hepatitis B virus infected livers
Department
Dept. of Pathology (병리학)
Publisher
Keimyung University School of Medicine
Citation
이상숙 et al. (1989). Hepatitis B Core Antigen의 간세포내 분포 양상에 대한 연구. Keimyung Medical Journal, 8(1), 97–103.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14565
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1989
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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