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Other Titles
An Immunocytochemical Assay of Estrogen Receptor in Breast Cancers Using Monoclonal Antibodies
Authors
김인호손수상강중신이상숙
Department
Dept. of Surgery (외과학); Dept. of Pathology (병리학)
Issue Date
1990
Citation
Keimyung Medical Journal, Vol.9(4) : 439-444, 1990
Abstract
Estrogen receptor(ER) is an unique protein that specifically binds estrogens in tissue that responds to this hormone. In order for tissue to recognize estrogens, it is considered necessary for ER to be present. Receptor assay can be used in prediction of response of hormonal therapy in treatment of breast cancers. Immunocytochemical assays(ICA) involve localization and staining of ER in tissues or cell preparations using monoclonal antibodies. Frozen sections from 13 human breast carcinomas were examined for the presence and distribution of ER-containing tumor cells using Abbott ER-ICA monoclonal antibodies and immunoperoxidase technique. Estrogen receptor was localized only in the nuclei in breast tumor cells in 6 cases. Serveral staining patterns were observed. Thus, an immunocytochemical assay for estrogen receptor may provide additional information for identifying hormonally responsive breast cancers.
Keywords
Breast cancerEstrogen receptor
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14657
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1990
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Keimyung Author(s)
김인호; 손수상; 강중신; 이상숙
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