당뇨병환자에 있어서 치료방법 선정에 식후 2시간 혈청 C-peptide치와 Glucagon자극후 혈청 C-peptide치의 의의

Other Titles
Glucagon-Stimulated and Postprandial Plasma C-peptide Values as a Guide for Insulin Treatment in Patients with Diabetes
Authors
서영숙손수인이인규안성훈이형우이현우
Department
Dept. of Internal Medicine (내과학)
Issue Date
1990
Citation
Keimyung Medical Journal, Vol.9(4) : 455-460, 1990
Abstract
Basal, postprandial (2hour after breakfast), and glucagon stimulated serum C-peptide concentrations were determined in 22 patients with diabetes who admitted in Keimyung University Dongsan Medical Center and Youngnam University Hospital. Basal and postprandial C-peptide values were measured on two consecutive days to estimate the degree of variation of C-peptide secretion. The results were as follows: 1. Mean fasting and postprandial C-peptide concentrations in 15 insulin requiring diabetic patients were 0.7±0.2ng/ml, 1.1±0.3ng/ml on first day. 0.9±0.4ng/ml, 1.1±0.4ng/ml on second day and in non insulin requiring diabetic patients were 1.5±0.5ng/ml, 2.5±0.7ng/ml on first day. 1.5±0.5ng/ml, 2.8±0.7ng/ml on second day. The mean C-peptide values of 15 insulin requiring diabetic patients were significantly lower than those of 7 non insulin requiring diabetic patients(p<0.05, p<0.001). 2. There were no differences in fasting and postprandial C-peptide values between two consecutive day. 3. The postprandial C-peptide valued on two consecutive days were postiviely correlated with the serum C-peptide values after a glucagon administration(r=0.86, 0.75). Above results suggested that postprandial and glucagon stimulated C-peptide valued are very sensitive guides for a insulin treatment in patients with diabetes.
Keywords
C-peptideDiabetesGlucagon
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14660
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
2. Keimyung Medical Journal (계명의대 학술지) > 1990
Keimyung Author(s)
이인규; 안성훈
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