당뇨병환자에 있어서 치료방법 선정에 식후 2시간 혈청 C-peptide치와 Glucagon자극후 혈청 C-peptide치의 의의

Abstract

Basal, postprandial (2hour after breakfast), and glucagon stimulated serum C-peptide concentrations were determined in 22 patients with diabetes who admitted in Keimyung University Dongsan Medical Center and Youngnam University Hospital. Basal and postprandial C-peptide values were measured on two consecutive days to estimate the degree of variation of C-peptide secretion. The results were as follows: 1. Mean fasting and postprandial C-peptide concentrations in 15 insulin requiring diabetic patients were 0.7±0.2ng/ml, 1.1±0.3ng/ml on first day. 0.9±0.4ng/ml, 1.1±0.4ng/ml on second day and in non insulin requiring diabetic patients were 1.5±0.5ng/ml, 2.5±0.7ng/ml on first day. 1.5±0.5ng/ml, 2.8±0.7ng/ml on second day. The mean C-peptide values of 15 insulin requiring diabetic patients were significantly lower than those of 7 non insulin requiring diabetic patients(p＜0.05, p＜0.001). 2. There were no differences in fasting and postprandial C-peptide values between two consecutive day. 3. The postprandial C-peptide valued on two consecutive days were postiviely correlated with the serum C-peptide values after a glucagon administration(r=0.86, 0.75). Above results suggested that postprandial and glucagon stimulated C-peptide valued are very sensitive guides for a insulin treatment in patients with diabetes.