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표피 종양에서 Epidermal Growth Factor Receptor의 발현비교

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Author(s)
이규석송준영
Alternative Author(s)
Lee, Kyu SukSong, Joon Young
Issued Date
1994
Keyword
Cutaneous epithelial tumorsEpidermal growth factor receptor
Abstract
Epidermal growth factor(EGF) and transforming growth factor alpha(TGFα) are important keratinocyte mitogens. Their effect are mediated by a cell membrane receptor(EGFR), quantitive and qualitive abnormalities of which may be responsible for deranged keratinocyte proliferation and differentiation. We have therefore examined EGFR expression immunohistochemically in a variety of benign and malignant epithelial neoplasms using monoclonal antibodies to the extracellular and intracellular receptor domains, In benign tumor(seborrheic keratosis), there was an ordered pattern of EGFR expression. In malignant tumors(basal and squamous cell carcinoma), there was loss of membrane labelling and cytoplasmic accumulation of the receptor. In premalignant prolifertation(Bowen's disease), there was loss of membrane receptor with absent cytoplasmic EGFR.
In slot-blot analysis, the levels of EGFR mRNA in sguamous cell carcinoma and basal cell carcinoma revealed 3 fold elevation when compared to normal skin.
We suggest that dysregulation of the EGFR may be important in the development of cutaneous epithelial malignancies.
Alternative Title
Expression of Epidermal Growth Factor Receptor in Epidermal Tumors
Department
Dept. of Dermatology (피부과학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.13(4) : 374-381, 1994
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/14895
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1994
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
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