계명대학교 의학도서관 Repository

표피 종양에서 Epidermal Growth Factor Receptor의 발현비교

Metadata Downloads
Author(s)
정재봉송준영이규석
Keimyung Author(s)
Lee, Kyu SukSong, Joon Young
Department
Dept. of Dermatology (피부과학)
Journal Title
Keimyung Medical Journal
Issued Date
1994
Volume
13
Issue
4
Keyword
Cutaneous epithelial tumorsEpidermal growth factor receptor
Abstract
Epidermal growth factor(EGF) and transforming growth factor alpha(TGFα) are important keratinocyte mitogens. Their effect are mediated by a cell membrane receptor(EGFR), quantitive and qualitive abnormalities of which may be responsible for deranged keratinocyte proliferation and differentiation. We have therefore examined EGFR expression immunohistochemically in a variety of benign and malignant epithelial neoplasms using monoclonal antibodies to the extracellular and intracellular receptor domains, In benign tumor(seborrheic keratosis), there was an ordered pattern of EGFR expression. In malignant tumors(basal and squamous cell carcinoma), there was loss of membrane labelling and cytoplasmic accumulation of the receptor. In premalignant prolifertation(Bowen's disease), there was loss of membrane receptor with absent cytoplasmic EGFR.
In slot-blot analysis, the levels of EGFR mRNA in sguamous cell carcinoma and basal cell carcinoma revealed 3 fold elevation when compared to normal skin.
We suggest that dysregulation of the EGFR may be important in the development of cutaneous epithelial malignancies.
Alternative Title
Expression of Epidermal Growth Factor Receptor in Epidermal Tumors
Keimyung Author(s)(Kor)
이규석
송준영
Publisher
Keimyung University School of Medicine
Citation
정재봉 et al. (1994). 표피 종양에서 Epidermal Growth Factor Receptor의 발현비교. Keimyung Medical Journal, 13(4), 374–381.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/14895
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1994
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.