만성 호중구성 백혈병 1례

Other Titles
A Case of Chronic Neutrophilic Leukemia
Authors
이홍석송홍석장용석박근규전동석
Department
Dept. of Internal Medicine (내과학); Dept. of Laboratory Medicine (진단검사의학); Institute of Medical Cytogenetics (유전의학연구소)
Issue Date
1999
Citation
Keimyung Medical Journal, Vol.18(4) : 540-547, 1999
Abstract
Chronic neutrophilic leukemia is a very rare myeloproliferative disorder of uncertain pathogenesis characterized by persistent neutrophilia without identifiable cause. Additionally chronic neutrophilic leukemia is characterized by hepatosplenomegaly, elevated leukocyte alkaline phosphatase, increased serum uric acid, bone marrow granulocyte hyperplasia, and the absence of philadephia chromosome. Recently we have experienced a case of neutrophilic leukemia in a 55 years old woman. On admission, peripheral blood leukocyte count was 94.000/㎕ and consist of 92% neutrophils. Many neutrophils had toxic granules, vacuoles and Dohle bodies. The underlying disease for leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score was elevated. The bone marrow smear showed myeloid hyperplasia. The cytogenetic study shows normal bone marrow cell karyotype without philadelphia chromosome. The patient died after 13 months from the treatment with hydrxoyurea and intermittent transfusion.
Keywords
Chronic neutrophilic leukemia
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15179
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
2. Keimyung Medical Journal (계명의대 학술지) > 1999
Keimyung Author(s)
박근규; 송홍석; 전동석
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