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만성 호중구성 백혈병 1례

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Author(s)
이홍석송홍석장용석박근규전동석
Keimyung Author(s)
Park, Keun GyuSong, Hong SukJeon, Dong Seok
Department
Dept. of Internal Medicine (내과학)
Dept. of Laboratory Medicine (진단검사의학)
Institute of Medical Cytogenetics (유전의학연구소)
Journal Title
Keimyung Medical Journal
Issued Date
1999
Volume
18
Issue
4
Keyword
Chronic neutrophilic leukemia
Abstract
Chronic neutrophilic leukemia is a very rare myeloproliferative disorder of uncertain pathogenesis characterized by persistent neutrophilia without identifiable cause. Additionally chronic neutrophilic leukemia is characterized by hepatosplenomegaly, elevated leukocyte alkaline phosphatase, increased serum uric acid, bone marrow granulocyte hyperplasia, and the absence of philadephia chromosome.
Recently we have experienced a case of neutrophilic leukemia in a 55 years old woman. On admission, peripheral blood leukocyte count was 94.000/㎕ and consist of 92% neutrophils. Many neutrophils had toxic granules, vacuoles and Dohle bodies. The underlying disease for leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score was elevated. The bone marrow smear showed myeloid hyperplasia. The cytogenetic study shows normal bone marrow cell karyotype without philadelphia chromosome. The patient died after 13 months from the treatment with hydrxoyurea and intermittent transfusion.
Alternative Title
A Case of Chronic
Neutrophilic Leukemia
Keimyung Author(s)(Kor)
박근규
송홍석
전동석
Publisher
Keimyung University School of Medicine
Citation
이홍석 et al. (1999). 만성 호중구성 백혈병 1례. Keimyung Medical Journal, 18(4), 540–547.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15179
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 1999
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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