Classification of Amyloidosis by Immunohistochemical Method and Potassium Permanganate Reaction: Correlation Between Morphology, Chemical Types and Clinical Features

Authors
박관규박성배김현철
Department
Dept. of Pathology (병리학); Dept. of Internal Medicine (내과학)
Issue Date
2000
Citation
Keimyung Medical Journal, Vol.19(1) : 1, 2000
Abstract
Systemic amyloidosis is a rare disorder, which usually occurs in aged people with a poor prognosis. Forty-five patients with amyloidosis were studied by light microscopy with Congo red staining, potassium permanganate reaction and immunohistochemistry. The biopsy sites were abdominal fat, rectum, lung, bone marrow, liver, pleura, duodenum, gallbladder, colon, oral cavity, larynx, thyroid and skin. The patients were classified according to immunohisto-chemistry and Congo red staining results after potassium permanganate treatment. Thus, 21 of 45(46.7%) cases were classified as AA (amyloid A protein), and 24(53.3%) cases were classified as AL(amyloid light chain) amyloidosis. This study suggests that the association of these two techniques, potassium permanganate reaction and immunohistochemical stain, is more reliable than clinical data alone in distinguishing between AA and AL amyloidosis.
Keywords
AA amyloidosisPotassium permanganateImmunohistochemistryAL amyloidosis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15181
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
2. Keimyung Medical Journal (계명의대 학술지) > 2000
Keimyung Author(s)
박관규; 박성배; 김현철
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