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일측 폐이식 성견에서 혈역학과 체액조절 호르몬의 상관관계

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Author(s)
박창권송대규배재훈박원균
Alternative Author(s)
Park, Chang KwonSong, Dae KyuBae, Jae HoonPark, Won Kyun
Publication Year
2002
Keyword
Atrial natriuretic peptideAntidiuretic hormoneHemodynamicsCanine single lung transplantation
Abstract
The purpose of this investigation was to study changes of plasma
atrial natriuretic peptide (ANP) and antidiuretic hormone (ADH) in Korean mongrel
dogs after a left single lung transplantation and to evaluate the correlation
between hemodynamic factors and secretory responses of ANP and ADH. Arterial
Po2 and Pco2 did not change significantly. Femoral arterial pressure decreased
after 30 min of reperfusion and recovered slightly at 120 min, whereas pulse pressure
did not change. After pneumonectomy, systolic pulmonary arterial pressure
increased, whereas diastolic pulmonary pressure remained unchanged. Althought
cardiac output fell following pneumonectomy and reperfusion, heart rate was
unchanged. The secretion of plasma ANP initially increased follwoing pneumonectomy,
but subsequently recoverd. In each subject, ANP values showed stronger
correlation with arterial Po2 than other hemodynamic parameters. The secretion of
plasma ADH also initially increased (p<0.05) after 30 min of reperfusion and
thereafter recoverd, showing the strongest correlation with mean femoral arterial
pressure. The present results suggest that the secretion of ANP and ADH seem to
be well regulated in accordance with hemodynamic changes after a single lung
transplantation. Hypoxia and systemic arterial pressure are the prominent factors
in the secretion of ANP and ADH, respectively.
Alternative Title
Correlation of
Hemodynamics and Hormones Regulating
Body Fluid in Canine with Single Lung Transplantation
Department
Dept. of Thoracic &amp; Cardiovascular Surgery (흉부외과학)
Dept. of Physiology (생리학)
Dept. of Medical Education (의학교육학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(1) : 27-41, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15237
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