쥐 재생간에서의 Arylamine N-Methyltransferase 활성도
- 김여희; 곽춘식
- Alternative Author(s)
- Kim, You Hee; Kwak, Chun Sik
- Publication Year
N-methyltransferase; Partial hepatectomy; Regenerating
- Changes of arylamine N-methyltransferase (AMT) activity during
regeneration of rat liver was studied. Cytosolic, mitochondrial and microsomal
AMT activities were determined in regenerating rat livers over a period of ten
days after 70％ (median and left lateral lobes) partial hepatectomy. The enzyme
activity in serum, and Km and Vmax values of the hepatic enzyme were also measured.
The activities of cytosolic and mitochondrial AMT were found to be significantly
increased between the first and the second day of regenerating rat liver,
whereas microsomal AMT increased between the first and the third day after partial
hepatectpmy. On the other hand, the serum AMT activity did not change. The
Vmax values of the cytosolic, mitochondrial and microsomal AMT in the regenerating
rat liver were significantly increased at the second day after partial hepatectomy,
however, the Km values of the above hepatic enzymes did not vary in all
experimental groups. Therefore, the above results indicate that the biosynthesis of
AMT was increased during the regeneration of rat liver.
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