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Author(s)
박종욱권택규
Alternative Author(s)
Park, Jong WookKwon, Taeg Kyu
Issued Date
2002
Keyword
Core antigenHepatitis B virusVaccine
Abstract
In order to develop effective vaccine to recover incomplete immunity
in patients with chronic hepatitis B virus infection, we produced various types of
vaccine for Hepatitis B virus core (HBc) antigen and compared their effects on
anti-HBc antibody response. Intramuscular injection of HBc DNA vaccine (pc
-HBc) and intraperitoneal injection of HBc-transfected Renca and EL-4 effectively
induced anti-HBc antibody response in mouse. Lipopolysaccharide (LPS) induced
gene expressions of IP-10, GM-CSF, and IL-12 in dendritic cell (DC). However,
LPS-stimulated DC or peritoneal macrophage, that were trasnsfected with HBc
mRNA, on HBc mRNA vaccine itself induced lower anti-HBc antibody response in
mouse compared to pc-HBc vaccine. These results suggest HBc DNA vaccine is
more simple and effective for the induction of anti-HBc antibody response than
HBc mRNA or mRNA-transfected cell vaccine.
Alternative Title
Induction of
Antiviral Antibody using HBV Gene and HBV mRNA Pulsed
Antigen Presenting Cell
Department
Dept. of Immunology (면역학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.21(2) : 191, 2002
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15255
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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