계명대학교 의학도서관 Repository

B형 간염바이러스 유전자 및 유전자 이입 항원제공세포를 이용한 항바이러스 항체생성 유도

Metadata Downloads
Author(s)
박종욱권택규
Keimyung Author(s)
Park, Jong WookKwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Keimyung Medical Journal
Issued Date
2002
Volume
21
Issue
2
Keyword
Core antigenHepatitis B virusVaccine
Abstract
In order to develop effective vaccine to recover incomplete immunity
in patients with chronic hepatitis B virus infection, we produced various types of
vaccine for Hepatitis B virus core (HBc) antigen and compared their effects on
anti-HBc antibody response. Intramuscular injection of HBc DNA vaccine (pc
-HBc) and intraperitoneal injection of HBc-transfected Renca and EL-4 effectively
induced anti-HBc antibody response in mouse. Lipopolysaccharide (LPS) induced
gene expressions of IP-10, GM-CSF, and IL-12 in dendritic cell (DC). However,
LPS-stimulated DC or peritoneal macrophage, that were trasnsfected with HBc
mRNA, on HBc mRNA vaccine itself induced lower anti-HBc antibody response in
mouse compared to pc-HBc vaccine. These results suggest HBc DNA vaccine is
more simple and effective for the induction of anti-HBc antibody response than
HBc mRNA or mRNA-transfected cell vaccine.
Alternative Title
Induction of
Antiviral Antibody using HBV Gene and HBV mRNA Pulsed
Antigen Presenting Cell
Keimyung Author(s)(Kor)
박종욱
권택규
Publisher
Keimyung University School of Medicine
Citation
박종욱 and 권택규. (2002). B형 간염바이러스 유전자 및 유전자 이입 항원제공세포를 이용한 항바이러스 항체생성 유도. Keimyung Medical Journal, 21(2), 191–201.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15255
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2002
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.