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담즙울체 쥐에서 간의 Glyoxalase Ⅱ 활성도에 미치는 Taurocholate의 정맥 내 투여의 효과

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Author(s)
곽춘식김여희
Alternative Author(s)
Kwak, Chun SikKim, You Hee
Publication Year
2003
Keyword
Bile duct obstructionCholedocho-caval shuntGlyoxalase ⅡTaurocholic acidTauroursodeoxycholic acid
Abstract
The possible mechanisms of decreased glyoxalase Ⅱ (GLO-Ⅱ)
activity in cholestatic rat liver was studied. Hepatic GLO-Ⅱ activity was
determined from the experimental rats with choledocho-caval shunt (CCS) or bile
duct obstruction (BDO). The Michaelis-Menten constant in this hepatic enzyme
was also measured. The activity of hepatic GLO-Ⅱ as well as the Vmax value was
found to be decreased significantly in both CCS plus taurocholic acid (TCA)
injection group, and BDO plus TCA injection group than in each control group
such as CCS alone and BDO alone. However, the GLO-Ⅱ activity did not change
in both the CCS plus tauroursodeoxycholic acid injection group and the BDO plus
tauroursodeoxycholic acid injection group. On the other hand, the Km value of the
GLO-Ⅱ did not vary in any experimental groups. Above results suggest that TCA
repress the biosynthesis of GLO-II in the liver.
Alternative Title
Effect of Intravenous
Administration of Taurocholate on
Hepatic Glyoxalase II Activity in Cholestatic Rats
Department
Dept. of Biochemistry (생화학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.22(1) : 31-40, 2003
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15263
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