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심뇌혈관 환자에서 Asprin 및 Clopidorel 저항군과 반응군 간 혈액학적 지표 비교

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Affiliated Author(s)
이원목하정숙류남희전동석김재룡
Alternative Author(s)
Lee, Won MokHa, Jung SookRyoo, Nam HeeJeon, Dong SeokKim, Jae Ryong
Journal Title
Keimyung Medical Journal
Issued Date
2013
Keyword
AspirinClopidogrelHematologic indexResistance
Abstract
It is important to detect aspirin and clopidogrel resistance to improve clinical outcomes in atherothrombotic disorders. This study aimed to investigate any hematologic parameter to predict anti-platelet agents resistance. 543 patients who had been treated with dual therapy for 2 weeks were divided into 4 groups using the drug resistance test, VerifyNow (Accumetrics, USA): nonresponders to both aspirin and clopidogrel (group A), non-responders to only aspirin (group B), non-responders to only clopidogrel (group C), and responders to both aspirin and clopidogrel (group D). Hematologic findings were collected before and after dual therapy. The platelet count in group B and the WBC count in group C were lower compared to group D before therapy. After medication, the platelet counts in groups A and C were lower than that of group D. However, all of these changes were developed within normal limits. When analyzing hematologic changes in each group before and after medication, the platelet count in group A was increased although other groups showed decreasing pattern of platelets. In conclusion, no profound hematologic index was found to suggest anti-platelet drug resistance, but the evaluation of hematologic changes before and after anti-platelet medication may be potential predictive parameters.
Alternative Title
A Comparison of Hematologic Indices between Aspirin/Clopidogrel Responders and Non-responders in Patients with Cardiovascular Disorders
Department
Dept. of Laboratory Medicine (진단검사의학)
Publisher
Keimyung University School of Medicine
Citation
Keimyung Medical Journal, Vol.32(1) : 51-60, 2013
Type
Article
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/15595
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2013
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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