심뇌혈관 환자에서 Asprin 및 Clopidorel 저항군과 반응군 간 혈액학적 지표 비교

Abstract

It is important to detect aspirin and clopidogrel resistance to improve clinical outcomes in atherothrombotic disorders. This study aimed to investigate any hematologic parameter to predict anti-platelet agents resistance. 543 patients who had been treated with dual therapy for 2 weeks were divided into 4 groups using the drug resistance test, VerifyNow (Accumetrics, USA): nonresponders to both aspirin and clopidogrel (group A), non-responders to only aspirin (group B), non-responders to only clopidogrel (group C), and responders to both aspirin and clopidogrel (group D). Hematologic findings were collected before and after dual therapy. The platelet count in group B and the WBC count in group C were lower compared to group D before therapy. After medication, the platelet counts in groups A and C were lower than that of group D. However, all of these changes were developed within normal limits. When analyzing hematologic changes in each group before and after medication, the platelet count in group A was increased although other groups showed decreasing pattern of platelets. In conclusion, no profound hematologic index was found to suggest anti-platelet drug resistance, but the evaluation of hematologic changes before and after anti-platelet medication may be potential predictive parameters.