Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model

In-Cheol KimChang-Wook NamYun-Kyeong ChoHyoung-Seob ParkHyuck-Jun YoonHyungseop KimIn-Sung ChungSeongwook HanSeung-Ho HurYoon-Nyun KimKwon-Bae Kim
Dept. of Internal Medicine (내과학)
Issue Date
International Journal of Cardiology, Vol.221() : 860-866, 2016
Background. This purpose of this study is to evaluate, concomitantly with quantitative coronary angiography (QCA), the potential discrepancy between frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) measurements in a phantom coronary model and in human coronary arteries within and outside stented segments. Methods. FD-OCT and IVUS images sequentially obtained from a phantom coronary model and 57 stented human coronary arteries were compared between each other and with QCA. Results. Lumen area (LA) by IVUS was 10.1% larger (6.43 ± 0.09 mm2) while by FD-OCT was similar (5.78 ± 0.09 mm2) to actual phantom LA (5.72 mm2); IVUS vs. FD-OCT stent area (SA) was 4.2% larger. In human coronary artery, diameter by QCA was smaller than by IVUS and OCT in reference (by 10.5% and 3.5%, both p < 0.001) and stented (3.6%, p < 0.001; and 1.7%, p = 0.012) segments. IVUS vs. FD-OCT distal reference LA was significantly larger (6.19 ± 2.18 mm2 vs. 5.49 ± 2.49 mm2, p < 0.001, respectively), and SA was numerically larger (7.42 ± 2.28 mm2 vs. 7.22 ± 2.48 mm2, p = 0.059) with larger discrepancy in reference (11.3%) than stented (2.7%) segments. IVUS vs. FD-OCT correlation for diameter was significantly higher for stented than reference segments (R2 = 0.8670 vs. 0.7351, p = 0.047), while numerically higher for area (R2 = 0.8663 vs. 0.7806, p = 0.157). Conclusions. In phantom model and human coronary arteries, IVUS vs. FD-OCT measurements were larger, particularly in non-stented than stented segments, and diameter was smaller by QCA vs. IVUS or FD-OCT. Despite undefined clinical significance, said discrepancy warrants consideration.
Frequency domain optical coherence tomographyIntravascular ultrasoundSize discrepancy
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1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
허승호; 김형섭; 박형섭; 윤혁준; 김윤년; 조윤경; 정인성; 남창욱; 김인철; 한성욱; 김권배
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