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Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model

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Author(s)
In-Cheol KimChang-Wook NamYun-Kyeong ChoHyoung-Seob ParkHyuck-Jun YoonHyungseop KimIn-Sung ChungSeongwook HanSeung-Ho HurYoon-Nyun KimKwon-Bae Kim
Keimyung Author(s)
Hur, Seung HoKim, Hyung SeopPark, Hyoung SeobYoon, Hyuck JunKim, Yoon NyunCho, Yun KyeongChung, In SungNam, Chang WookKim, In CheolHan, Seong WookKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Cardiology
Issued Date
2016
Volume
221
Keyword
Frequency domain optical coherence tomographyIntravascular ultrasoundSize discrepancy
Abstract
Background.


This purpose of this study is to evaluate, concomitantly with quantitative coronary angiography (QCA), the potential discrepancy between frequency domain optical coherence tomography (FD-OCT) and intravascular ultrasound (IVUS) measurements in a phantom coronary model and in human coronary arteries within and outside stented segments.



Methods.


FD-OCT and IVUS images sequentially obtained from a phantom coronary model and 57 stented human coronary arteries were compared between each other and with QCA.



Results.


Lumen area (LA) by IVUS was 10.1% larger (6.43 ± 0.09 mm2) while by FD-OCT was similar (5.78 ± 0.09 mm2) to actual phantom LA (5.72 mm2); IVUS vs. FD-OCT stent area (SA) was 4.2% larger. In human coronary artery, diameter by QCA was smaller than by IVUS and OCT in reference (by 10.5% and 3.5%, both p < 0.001) and stented (3.6%, p < 0.001; and 1.7%, p = 0.012) segments. IVUS vs. FD-OCT distal reference LA was significantly larger (6.19 ± 2.18 mm2 vs. 5.49 ± 2.49 mm2, p < 0.001, respectively), and SA was numerically larger (7.42 ± 2.28 mm2 vs. 7.22 ± 2.48 mm2, p = 0.059) with larger discrepancy in reference (11.3%) than stented (2.7%) segments. IVUS vs. FD-OCT correlation for diameter was significantly higher for stented than reference segments (R2 = 0.8670 vs. 0.7351, p = 0.047), while numerically higher for area (R2 = 0.8663 vs. 0.7806, p = 0.157).



Conclusions.


In phantom model and human coronary arteries, IVUS vs. FD-OCT measurements were larger, particularly in non-stented than stented segments, and diameter was smaller by QCA vs. IVUS or FD-OCT. Despite undefined clinical significance, said discrepancy warrants consideration.
Keimyung Author(s)(Kor)
허승호
김형섭
박형섭
윤혁준
김윤년
조윤경
정인성
남창욱
김인철
한성욱
김권배
Publisher
School of Medicine
Citation
In-Cheol Kim et al. (2016). Discrepancy between frequency domain optical coherence tomography and intravascular ultrasound in human coronary arteries and in a phantom in vitro coronary model. International Journal of Cardiology, 221, 860–866. doi: 10.1016/j.ijcard.2016.07.080
Type
Article
ISSN
0167-5273
DOI
10.1016/j.ijcard.2016.07.080
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32421
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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