Temporal Improvement in Survival of Patients with Hepatocellular Carcinoma in a Hepatitis B Virus-Endemic Population.

Authors
Bo Hyun KimYoung‐Suk LimEun‐Yang KimHyun‐Joo KongYoung‐Joo WonSeungbong HanSohee ParkJae Seok Hwang
Department
Dept. of Internal Medicine (내과학)
Citation
Journal of Gastroenterology and Hepatology, Vol.33(2) : 475-483, 2018
ISSN
0815-9319
Abstract
Background and Aim: Over the past decade, the management of hepatocellular carcinoma (HCC) and viral hepatitis has been improved. We explored survival trends and factors affecting survival of HCC in a hepatitis B virus (HBV)-endemic population. Methods: From 31 521 and 38 167 HCC registrants to the population-based national cancer registry in Korea, an HBV-endemic country, in the period of 2003–2005 and 2008–2010, we randomly sampled cohorts of 4515 and 4582 patients, respectively, for the investigation of clinical characteristics and survival. Results: Compared with Cohort 2003–2005, Cohort 2008 –2010 had significantly better liver function (Child–Turcotte–Pugh class A, 64.2% vs 71.6%; P < 0.001) and had more advanced tumor stages (Barcelona Clinic Liver Cancer stage B–D, 45.8% vs 50.4%; P < 0.001). HBV was the predominant cause of HCC in both cohorts (62.5% vs 62.2%; P = 0.70). Cohort 2008–2010 had significantly better overall survival than Cohort 2003–2005 by age-adjusted univariate, multivariable, and propensity score-matched analy- ses (median survival time, 17.2 vs 28.4 months; P < 0.001). In a subcohort analysis, a consistently significant inter-cohort improvement in survival was observed only in patients with HBV-related HCC (median survival, 16.1 vs 30.4 months; P < 0.001). The annual number of patients with HCC receiving oral antiviral agents for HBV precipitously increased from 93 in 2005 to 28 520 in 2010 in the country. Conclusions: The consistent improvement in survival of patients with HCC was confined to HBV-related HCC subcohort over the last decade in an HBV-endemic population. The survival improvement coincided with the exponential use of oral antiviral agents for HBV in the patients.
Keywords
hepatitis B virushepatitis C virushepatocellular carcinomapopulationregistry
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/32785
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
황재석
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.13848
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