Temporal Improvement in Survival of Patients with Hepatocellular Carcinoma in a Hepatitis B Virus-Endemic Population.
- Bo Hyun Kim; Young‐Suk Lim; Eun‐Yang Kim; Hyun‐Joo Kong; Young‐Joo Won; Seungbong Han; Sohee Park; Jae Seok Hwang
- Dept. of Internal Medicine (내과학)
- Journal of Gastroenterology and Hepatology, Vol.33(2) : 475-483, 2018
- Background and Aim: Over the past decade, the management of hepatocellular carcinoma
(HCC) and viral hepatitis has been improved. We explored survival trends and factors
affecting survival of HCC in a hepatitis B virus (HBV)-endemic population.
Methods: From 31 521 and 38 167 HCC registrants to the population-based national
cancer registry in Korea, an HBV-endemic country, in the period of 2003–2005 and
2008–2010, we randomly sampled cohorts of 4515 and 4582 patients, respectively, for
the investigation of clinical characteristics and survival.
Results: Compared with Cohort 2003–2005, Cohort 2008 –2010 had signiﬁcantly better
liver function (Child–Turcotte–Pugh class A, 64.2% vs 71.6%; P < 0.001) and had more
advanced tumor stages (Barcelona Clinic Liver Cancer stage B–D, 45.8% vs 50.4%;
P < 0.001). HBV was the predominant cause of HCC in both cohorts (62.5% vs 62.2%;
P = 0.70). Cohort 2008–2010 had signiﬁcantly better overall survival than Cohort
2003–2005 by age-adjusted univariate, multivariable, and propensity score-matched analy-
ses (median survival time, 17.2 vs 28.4 months; P < 0.001). In a subcohort analysis, a
consistently signiﬁcant inter-cohort improvement in survival was observed only in patients
with HBV-related HCC (median survival, 16.1 vs 30.4 months; P < 0.001). The annual
number of patients with HCC receiving oral antiviral agents for HBV precipitously
increased from 93 in 2005 to 28 520 in 2010 in the country.
Conclusions: The consistent improvement in survival of patients with HCC was conﬁned
to HBV-related HCC subcohort over the last decade in an HBV-endemic population. The
survival improvement coincided with the exponential use of oral antiviral agents for HBV
in the patients.
- hepatitis B virus; hepatitis C virus; hepatocellular carcinoma; population; registry
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- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
- Keimyung Author(s)
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