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Temporal Improvement in Survival of Patients with Hepatocellular Carcinoma in a Hepatitis B Virus-Endemic Population.

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Author(s)
Bo Hyun KimYoung‐Suk LimEun‐Yang KimHyun‐Joo KongYoung‐Joo WonSeungbong HanSohee ParkJae Seok Hwang
Keimyung Author(s)
Hwang, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Gastroenterology and Hepatology
Issued Date
2018
Volume
33
Issue
2
Keyword
hepatitis B virushepatitis C virushepatocellular carcinomapopulationregistry
Abstract
Background and Aim: Over the past decade, the management of hepatocellular carcinoma
(HCC) and viral hepatitis has been improved. We explored survival trends and factors
affecting survival of HCC in a hepatitis B virus (HBV)-endemic population.
Methods: From 31 521 and 38 167 HCC registrants to the population-based national
cancer registry in Korea, an HBV-endemic country, in the period of 2003–2005 and
2008–2010, we randomly sampled cohorts of 4515 and 4582 patients, respectively, for
the investigation of clinical characteristics and survival.
Results: Compared with Cohort 2003–2005, Cohort 2008 –2010 had significantly better
liver function (Child–Turcotte–Pugh class A, 64.2% vs 71.6%; P < 0.001) and had more
advanced tumor stages (Barcelona Clinic Liver Cancer stage B–D, 45.8% vs 50.4%;
P < 0.001). HBV was the predominant cause of HCC in both cohorts (62.5% vs 62.2%;
P = 0.70). Cohort 2008–2010 had significantly better overall survival than Cohort
2003–2005 by age-adjusted univariate, multivariable, and propensity score-matched analy-
ses (median survival time, 17.2 vs 28.4 months; P < 0.001). In a subcohort analysis, a
consistently significant inter-cohort improvement in survival was observed only in patients
with HBV-related HCC (median survival, 16.1 vs 30.4 months; P < 0.001). The annual
number of patients with HCC receiving oral antiviral agents for HBV precipitously
increased from 93 in 2005 to 28 520 in 2010 in the country.
Conclusions: The consistent improvement in survival of patients with HCC was confined
to HBV-related HCC subcohort over the last decade in an HBV-endemic population. The
survival improvement coincided with the exponential use of oral antiviral agents for HBV
in the patients.
Keimyung Author(s)(Kor)
황재석
Publisher
School of Medicine
Citation
Bo Hyun Kim et al. (2018). Temporal Improvement in Survival of Patients with Hepatocellular Carcinoma in a Hepatitis B Virus-Endemic Population. Journal of Gastroenterology and Hepatology, 33(2), 475–483. doi: 10.1111/jgh.13848
Type
Article
ISSN
0815-9319
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.13848
DOI
10.1111/jgh.13848
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32785
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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