A Comparison of Echocardiographic Variables of Right Ventricular Function with Exercise Capacity After Bosentan Treatment in Patients with Pulmonary Arterial Hypertension: Results from a Multicenter, Prospective, Cohort Study

Abstract

Purpose. Bosentan reduces pulmonary arterial pressure and improves exercise capacity in patients with pulmonary arterial hypertension (PAH). However, there are limited data regarding the extent to which the changes in echocardiographic variables reflect improvements in exercise capacity. We aimed to assess the improvement of echocardiographic varia- bles and exercise capacity after 6 months of bosentan treatment for PAH. Methods. We performed a prospective study from June 2012 to June 2015 in seven participating medical centers. Echocardiography, including tissue Doppler imaging (TDI) and the 6-minute walk test distance (6MWD), was performed at baseline and after 6 months of bosentan treatment. Results. We analyzed 19 patients with PAH: seven with congenital shunt, six with collagen vascular dis- ease, and six with idiopathic PAH. After bosentan treatment, mean 6MWD increased by 50 meters. Right ventricle (RV) systolic pressure, tricuspid annular plane systolic excursion, myocardial performance index (MPI) derived from TDI (MPI-TDI) of RV and left ventricle (LV), RV fractional area change, and RV ejec- tion fraction were significantly improved. In particu- lar, the magnitude of RV and LV MPI-TDI showed good correlation with changes in the 6MWD. Conclusions. The magnitude of RV and LV MPI-TDI was strongly associated with improvements in exer- cise capacity.