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A Comparison of Echocardiographic Variables of Right Ventricular Function with Exercise Capacity After Bosentan Treatment in Patients with Pulmonary Arterial Hypertension: Results from a Multicenter, Prospective, Cohort Study

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Author(s)
Hyungseop KimJin Bae LeeJae‐Hyeong ParkByung‐Su YooJang‐Won SonDong Heon YangBong‐Ryeol Lee
Keimyung Author(s)
Kim, Hyung Seop
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Clinical Ultrasound
Issued Date
2017
Volume
45
Issue
1
Keyword
pulmonary arterial hypertensionmyocardial performance indextissue Doppler imagingbosentan
Abstract
Purpose. Bosentan reduces pulmonary
arterial pressure and improves exercise capacity in
patients with pulmonary arterial hypertension (PAH).
However, there are limited data regarding the extent to
which the changes in echocardiographic variables
reflect improvements in exercise capacity. We aimed
to assess the improvement of echocardiographic varia-
bles and exercise capacity after 6 months of bosentan
treatment for PAH.
Methods. We performed a prospective study from
June 2012 to June 2015 in seven participating medical
centers. Echocardiography, including tissue Doppler
imaging (TDI) and the 6-minute walk test distance
(6MWD), was performed at baseline and after 6
months of bosentan treatment.
Results. We analyzed 19 patients with PAH: seven
with congenital shunt, six with collagen vascular dis-
ease, and six with idiopathic PAH. After bosentan
treatment, mean 6MWD increased by 50 meters. Right ventricle (RV) systolic pressure, tricuspid annular
plane systolic excursion, myocardial performance
index (MPI) derived from TDI (MPI-TDI) of RV and left
ventricle (LV), RV fractional area change, and RV ejec-
tion fraction were significantly improved. In particu-
lar, the magnitude of RV and LV MPI-TDI showed
good correlation with changes in the 6MWD.
Conclusions. The magnitude of RV and LV MPI-TDI
was strongly associated with improvements in exer-
cise capacity.
Keimyung Author(s)(Kor)
김형섭
Publisher
School of Medicine
Citation
Hyungseop Kim et al. (2017). A Comparison of Echocardiographic Variables of Right Ventricular Function with Exercise Capacity After Bosentan Treatment in Patients with Pulmonary Arterial Hypertension: Results from a Multicenter, Prospective, Cohort Study. Journal of Clinical Ultrasound, 45(1), 28–34. doi: 10.1002/jcu.22396
Type
Article
ISSN
0091-2751
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jcu.22396
DOI
10.1002/jcu.22396
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32792
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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