대상포진 환자에서 임상 중증도와 혈청 Varicella-zoster Virus DNA 농도와의 관계

Other Titles
Correlation between Severity of Clinical Features and Serum Varicella-zoster Virus DNA Titer in Patients with Herpes Zoster
Authors
김수현하정숙김성애
Department
Dept. of Laboratory Medicine (진단검사의학); Dept. of Dermatology (피부과학)
Issue Date
2016
Citation
대한피부과학회지, Vol.54(7) : 509-515, 2016
ISSN
0494-4739
Abstract
BACKGROUND: Varicella-zoster virus (VZV) DNA can be detected in serum specimens of herpes zoster patients despite its cell-associated nature. We expected that quantitation of the VZV DNA in the serum was of potential importance for predicting the clinical severity in patients with herpes zoster. OBJECTIVE: The purpose of this study was to identify the correlation between the severity of clinical features and serum VZV titers in patients with herpes zoster. METHODS: Between December 2013 and January 2015, a total of 31 patients were included in this study. The patients were divided into two groups according to clinical features: skin inflammation severity, initial pain, age, lesion site, and underlying diseases. Samples were also collected from five adults without any VZV-induced symptoms. Viral DNA amplification by real-time polymerase chain reaction was examined in all patients. RESULTS: The median serum VZV DNA titer of the severe inflammation group (826.25 copies/µL) was significantly higher than that of mild inflammation group (567.5 copies/µL) (p<0.05). There was no significant correlation between the serum VZV titer and severity of initial pain, age, lesion site, and underlying diseases. No serum VZV DNA was detected in the control group. CONCLUSION: In conclusion, the serum VZV DNA titer was related to the skin inflammation severity of patients with herpes zoster.
Keywords
CorrelationDNA titerHerpes zosterReal-time PCRVaricella-zoster virus
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/32818
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
Keimyung Author(s)
하정숙; 김성애
Full Text
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3461188
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