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대상포진 환자에서 임상 중증도와 혈청 Varicella-zoster Virus DNA 농도와의 관계

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Author(s)
김수현하정숙김성애
Keimyung Author(s)
Kim, Sung AeHa, Jung Sook
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Dermatology (피부과학)
Journal Title
대한피부과학회지
Issued Date
2016
Volume
54
Issue
7
Keyword
CorrelationDNA titerHerpes zosterReal-time PCRVaricella-zoster virus
Abstract
BACKGROUND: Varicella-zoster virus (VZV) DNA can be detected in serum specimens of herpes zoster patients despite its cell-associated nature. We expected that quantitation of the VZV DNA in the serum was of potential importance for predicting the clinical severity in patients with herpes zoster. OBJECTIVE: The purpose of this study was to identify the correlation between the severity of clinical features and serum VZV titers in patients with herpes zoster. METHODS: Between December 2013 and January 2015, a total of 31 patients were included in this study. The patients were divided into two groups according to clinical features: skin inflammation severity, initial pain, age, lesion site, and underlying diseases. Samples were also collected from five adults without any VZV-induced symptoms. Viral DNA amplification by real-time polymerase chain reaction was examined in all patients. RESULTS: The median serum VZV DNA titer of the severe inflammation group (826.25 copies/µL) was significantly higher than that of mild inflammation group (567.5 copies/µL) (p<0.05). There was no significant correlation between the serum VZV titer and severity of initial pain, age, lesion site, and underlying diseases. No serum VZV DNA was detected in the control group. CONCLUSION: In conclusion, the serum VZV DNA titer was related to the skin inflammation severity of patients with herpes zoster.
Alternative Title
Correlation between Severity of Clinical Features and Serum Varicella-zoster Virus DNA Titer in Patients with Herpes Zoster
Keimyung Author(s)(Kor)
하정숙
김성애
Publisher
School of Medicine
Citation
김수현 et al. (2016). 대상포진 환자에서 임상 중증도와 혈청 Varicella-zoster Virus DNA 농도와의 관계. 대한피부과학회지, 54(7), 509–515.
Type
Article
ISSN
0494-4739
Source
http://kiss.kstudy.com/thesis/thesis-view.asp?key=3461188
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32818
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dermatology (피부과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
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