Altered microRNA expression profile in hepatitis B virus-related hepatocellular carcinoma
- Affiliated Author(s)
- 박건욱; 김진영; 황일선; 강구정
- Alternative Author(s)
- Park, Keon Uk; Kim, Jin Young; Hwang, Il Seon; Kang, Koo Jeong
- Journal Title
- Gene
- ISSN
- 0378-1119
- Issued Date
- 2015
- Keyword
- HCC; MicroRNA array; Expression profile
- Abstract
- Hepatocellular carcinoma (HCC) is one of the most lethal cancers, accounting for about 600,000 cancer deaths
worldwide. Despite aggressive chemotherapy, the 5-year survival rate is less than 30% in the United States.
This underscores the need for a better understanding of the molecular and cellular disease features.Many studies
have demonstrated that aberrant regulation of microRNA (miRNA) expression plays a critical role in the development
of various types of cancers including HCC. Here we analyzed the miRNA expression profile of HCC
cases associated with chronic hepatitis B virus infection, one of the major etiologies of HCC. Our study identified
267 miRNAs that were differentially regulated in HCC specimens compared to adjacent normal tissues. We next
analyzed putative target genes and the relevant signaling pathways that are regulated by these miRNAs. Our
findings support the notion that dysfunction of miRNAs is linked to HCC pathogenesis and may lead to the
identification of novel targets for diagnosing and treating HCC.
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