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Altered microRNA expression profile in hepatitis B virus-related hepatocellular carcinoma

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Author(s)
Keon Uk ParkYoung-Su SeoYun-Han LeeJungwook ParkIlseon HwangKoo Jeong KangJehyun NamSang-Woo KimJin Young Kim
Keimyung Author(s)
Park, Keon UkKim, Jin YoungHwang, Il SeonKang, Koo Jeong
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Institute for Cancer Research (암연구소)
Journal Title
Gene
Issued Date
2015
Volume
573
Issue
2
Keyword
HCCMicroRNA arrayExpression profile
Abstract
Hepatocellular carcinoma (HCC) is one of the most lethal cancers, accounting for about 600,000 cancer deaths
worldwide. Despite aggressive chemotherapy, the 5-year survival rate is less than 30% in the United States.
This underscores the need for a better understanding of the molecular and cellular disease features.Many studies
have demonstrated that aberrant regulation of microRNA (miRNA) expression plays a critical role in the development
of various types of cancers including HCC. Here we analyzed the miRNA expression profile of HCC
cases associated with chronic hepatitis B virus infection, one of the major etiologies of HCC. Our study identified
267 miRNAs that were differentially regulated in HCC specimens compared to adjacent normal tissues. We next
analyzed putative target genes and the relevant signaling pathways that are regulated by these miRNAs. Our
findings support the notion that dysfunction of miRNAs is linked to HCC pathogenesis and may lead to the
identification of novel targets for diagnosing and treating HCC.
Keimyung Author(s)(Kor)
박건욱
김진영
황일선
강구정
Publisher
School of Medicine
Citation
Keon Uk Park et al. (2015). Altered microRNA expression profile in hepatitis B virus-related hepatocellular carcinoma. Gene, 573(2), 278–284. doi: 10.1016/j.gene.2015.07.053
Type
Article
ISSN
0378-1119
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0378111915008781?via%3Dihub
DOI
10.1016/j.gene.2015.07.053
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32892
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
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