The Role of Autophagy in Hepatocellular Carcinoma
- Affiliated Author(s)
- 이유진; 장병국
- Alternative Author(s)
- Lee, Yoo Jin; Jang, Byoung Kuk
- Journal Title
- International Journal of Molecular Sciences
- ISSN
- 1422-0067
- Issued Date
- 2015
- Keyword
- Hepatocellular carcinoma; Autophagy; Tumorigenesis; Tumor suppression; Prognosis; Therapy
- Abstract
- Autophagy is a catabolic process involved in cellular homeostasis under basal and
stressed conditions. Autophagy is crucial for normal liver physiology and the pathogenesis of liver
diseases. During the last decade, the function of autophagy in hepatocellular carcinoma (HCC)
has been evaluated extensively. Currently, autophagy is thought to play a dual role in HCC, i.e.,
autophagy is involved in tumorigenesis and tumor suppression. Recent investigations of autophagy
have suggested that autophagy biomarkers can facilitate HCC prognosis and the establishment
of therapeutic approaches. In this review, we briefly summarize the current understanding of
autophagy and discuss recent evidence for its role in HCC.
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