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The Role of Autophagy in Hepatocellular Carcinoma

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Author(s)
Yoo Jin LeeByoung Kuk Jang
Keimyung Author(s)
Lee, Yoo JinJang, Byoung Kuk
Department
Dept. of Internal Medicine (내과학)
Journal Title
International Journal of Molecular Sciences
Issued Date
2015
Volume
16
Issue
11
Keyword
Hepatocellular carcinomaAutophagyTumorigenesisTumor suppressionPrognosisTherapy
Abstract
Autophagy is a catabolic process involved in cellular homeostasis under basal and
stressed conditions. Autophagy is crucial for normal liver physiology and the pathogenesis of liver
diseases. During the last decade, the function of autophagy in hepatocellular carcinoma (HCC)
has been evaluated extensively. Currently, autophagy is thought to play a dual role in HCC, i.e.,
autophagy is involved in tumorigenesis and tumor suppression. Recent investigations of autophagy
have suggested that autophagy biomarkers can facilitate HCC prognosis and the establishment
of therapeutic approaches. In this review, we briefly summarize the current understanding of
autophagy and discuss recent evidence for its role in HCC.
Keimyung Author(s)(Kor)
이유진
장병국
Publisher
School of Medicine
Citation
Yoo Jin Lee and Byoung Kuk Jang. (2015). The Role of Autophagy in Hepatocellular Carcinoma. International Journal of Molecular Sciences, 16(11), 26629–26643. doi: 10.3390/ijms161125984
Type
Article
ISSN
1422-0067
DOI
10.3390/ijms161125984
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33064
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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