계명대학교 의학도서관 Repository

Long-term outcomes of surgery and radiotherapy for secreting and non-secreting pituitary adenoma

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Affiliated Author(s)
김진희오영기김엘
Alternative Author(s)
Kim, Jin HeeOh, Young KeeKim, El
Journal Title
Radiation Oncology Journal
ISSN
2234-1900
Issued Date
2016
Keyword
Pituitary adenomaRadiotherapyTreatment outcomeComplication
Abstract
Purpose: To investigate treatment outcome and long term complication after surgery and radiotherapy (RT) for pituitary
adenoma.
Materials and Methods: From 1990 to 2009, 73 patients with surgery and RT for pituitary adenoma were analyzed in this
study. Median age was 51 years (range, 25 to 71 years). Median tumor size was 3 cm (range, 1 to 5 cm) with suprasellar (n = 21),
cavernous sinus extension (n = 14) or both (n = 5). Hormone secreting tumor was diagnosed in 29 patients; 16 patients with
prolactin, 12 patients with growth hormone, and 1 patient with adrenocorticotrophic hormone. Impairment of visual acuity or
visual field was presented in 33 patients at first diagnosis. Most patients (n = 64) received RT as postoperative adjuvant setting.
Median RT dose was 45 Gy (range, 45 to 59.4 Gy).
Results: Median follow-up duration was 8 years (range, 3 to 22 years). In secreting tumors, hormone normalization rate was 55%
(16 of 29 patients). For 25 patients with evaluable visual field and visual acuity test, 21 patients (84%) showed improvement of
visual disturbance after treatment. The 10-year tumor control rate for non-secreting and secreting adenoma was 100% and 58%,
respectively (p < 0.001). Progression free survival rate at 10 years was 98%. Only 1 patient experienced endocrinological recurrence.
Following surgery, 60% (n = 44) suffered from pituitary function deficit. Late complication associated with RT was only 1 patient,
who developed cataract.
Conclusion: Surgery and RT are very effective and safe in hormonal and tumor growth control for secreting and non-secreting
pituitary adenoma.
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