계명대학교 의학도서관 Repository

Long-term outcomes of surgery and radiotherapy for secreting and non-secreting pituitary adenoma

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Author(s)
Mi Young KimJin Hee KimYoung Kee OhEl Kim
Keimyung Author(s)
Kim, Jin HeeOh, Young KeeKim, El
Department
Dept. of Radiation Oncology (방사선종양학)
Dept. of Neurosurgery (신경외과학)
Journal Title
Radiation Oncology Journal
Issued Date
2016
Volume
34
Issue
2
Keyword
Pituitary adenomaRadiotherapyTreatment outcomeComplication
Abstract
Purpose: To investigate treatment outcome and long term complication after surgery and radiotherapy (RT) for pituitary
adenoma.
Materials and Methods: From 1990 to 2009, 73 patients with surgery and RT for pituitary adenoma were analyzed in this
study. Median age was 51 years (range, 25 to 71 years). Median tumor size was 3 cm (range, 1 to 5 cm) with suprasellar (n = 21),
cavernous sinus extension (n = 14) or both (n = 5). Hormone secreting tumor was diagnosed in 29 patients; 16 patients with
prolactin, 12 patients with growth hormone, and 1 patient with adrenocorticotrophic hormone. Impairment of visual acuity or
visual field was presented in 33 patients at first diagnosis. Most patients (n = 64) received RT as postoperative adjuvant setting.
Median RT dose was 45 Gy (range, 45 to 59.4 Gy).
Results: Median follow-up duration was 8 years (range, 3 to 22 years). In secreting tumors, hormone normalization rate was 55%
(16 of 29 patients). For 25 patients with evaluable visual field and visual acuity test, 21 patients (84%) showed improvement of
visual disturbance after treatment. The 10-year tumor control rate for non-secreting and secreting adenoma was 100% and 58%,
respectively (p < 0.001). Progression free survival rate at 10 years was 98%. Only 1 patient experienced endocrinological recurrence.
Following surgery, 60% (n = 44) suffered from pituitary function deficit. Late complication associated with RT was only 1 patient,
who developed cataract.
Conclusion: Surgery and RT are very effective and safe in hormonal and tumor growth control for secreting and non-secreting
pituitary adenoma.
Keimyung Author(s)(Kor)
김진희
오영기
김엘
Publisher
School of Medicine
Citation
Mi Young Kim et al. (2016). Long-term outcomes of surgery and radiotherapy for secreting and non-secreting pituitary adenoma. Radiation Oncology Journal, 34(2), 121–127. doi: 10.3857/roj.2016.01683
Type
Article
ISSN
2234-1900
DOI
10.3857/roj.2016.01683
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33232
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
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