The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study
- Affiliated Author(s)
- 류성열; 김현아
- Alternative Author(s)
- Ryu, Seong Yeol; Kim, Hyun Ah
- Journal Title
- American Journal of Infection Control
- ISSN
- 0196-6553
- Issued Date
- 2016
- Keyword
- Postexposure prophylaxis; Occupational exposure; Hepatitis B virus; Health care workers; Treatment outcomes
- Abstract
- Background: Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an
important role in the prevention of HBV infections in health care workers (HCWs). We examined data
concerning the acceptable duration between occupational exposure and administration of a hepatitis B
immunoglobulin (HBIG) injection in an occupational clinical setting.
Methods: A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in
15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from
the infection control records of each hospital.
Results: Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination
testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG
was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG
injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days.
Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion
to hepatitis b antibody positivity occurred.
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