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The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study

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Author(s)
Hyun-Ha ChangWon Kee LeeChisook MoonWon Suk ChoiHee-Jung YoonJieun KimSeong Yeol RyuHyun Ah KimYu Mi JoKi Tae KwonHye In KimJang Wook SohnYoung Kyung YoonSook In JungKyung-Hwa ParkHyun Hee KwonMi Suk LeeYoung-Keun KimYeon Sook KimJian HurShin-Woo Kim
Keimyung Author(s)
Ryu, Seong YeolKim, Hyun Ah
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Journal of Infection Control
Issued Date
2016
Volume
44
Issue
5
Keyword
Postexposure prophylaxisOccupational exposureHepatitis B virusHealth care workersTreatment outcomes
Abstract
Background: Postexposure prophylaxis for occupational exposure to hepatitis B virus (HBV) plays an
important role in the prevention of HBV infections in health care workers (HCWs). We examined data
concerning the acceptable duration between occupational exposure and administration of a hepatitis B
immunoglobulin (HBIG) injection in an occupational clinical setting.
Methods: A retrospective analysis was conducted with data from 143 cases of HCWs exposed to HBV in
15 secondary and tertiary teaching hospitals between January 2005 and June 2013. Data were taken from
the infection control records of each hospital.
Results: Active vaccination after HBV exposure was started in 119 cases (83.2%) and postvaccination
testing for hepatitis B antibody showed positive seroconversion in 93% of cases. In 98 cases (68.5%), HBIG
was administered within 24 hours after HBV exposure; however, 45 HCWs (31.5%) received an HBIG
injection more than 24 hours postexposure and 2 among the 45 received an injection after 7 days.
Although 31.5% received an HBIG injection more than 24 hours postexposure, no cases of seroconversion
to hepatitis b antibody positivity occurred.
Keimyung Author(s)(Kor)
류성열
김현아
Publisher
School of Medicine
Citation
Hyun-Ha Chang et al. (2016). The acceptable duration between occupational exposure to hepatitis B virus and hepatitis B immunoglobulin injection: Results from a Korean nationwide, multicenter study. American Journal of Infection Control, 44(5), 189–193–189–193. doi: 10.1016/j.ajic.2015.08.024
Type
Article
ISSN
0196-6553
Source
http://lps3.www.sciencedirect.com.proxy.dsmc.or.kr/science/article/pii/S0196655315009414?via%3Dihub
DOI
10.1016/j.ajic.2015.08.024
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33302
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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