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Two-Year Safety and Efficacy of Biodegradable Polymer Drug-Eluting Stent Versus Second-Generation Durable Polymer Drug-Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR).

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Affiliated Author(s)
허승호김인철조윤경윤혁준남창욱김권배
Alternative Author(s)
Hur, Seung HoKim, In CheolCho, Yun KyeongYoon, Hyuck JunNam, Chang WookKim, Kwon Bae
Journal Title
Cardiology Clinics
ISSN
0733-8651
Issued Date
2016
Abstract
Background: Despite improved long-term safety of biodegradable polymer (BP) drug-eluting stents (DES)
compared to first-generation durable polymer (DP) DES, data on the safety and efficacy of BP-DES compared with
second-generation (2G) DP-DES in patients with acute myocardial infarction (AMI) are limited.
Hypothesis: To evaluate the safety and efficacy of BP-DES compared with 2G-DP-DES in the higher stent
thrombosis (ST) risk setting of AMI.
Methods: A total of 3359 AMI patients who received either BP-DES (n=261) or 2G-DP-DES (n=3098) were
included from the Korea Acute Myocardial Infarction Registry (KAMIR). Differences in baseline clinical and
angiographic characteristics were adjusted using a 1:5 propensity score matching analysis (n=261 for BP-DES
and n=1305 for 2G-DP-DES). The primary outcome was the incidence of major adverse cardiac events (MACE)
including all-cause death, recurrent myocardial infarction (re-MI), and target vessel revascularization (TVR). The
rate of definite or probable ST was also investigated.
Results: In adjusted analysis, there was no significant difference between the 2 groups in baseline clinical
and angiographic characteristics; 2-year MACE (10.7% and 9.9% in the BP-DES group and 2G-DP-DES group,
respectively, P = 0.679); ST incidence (0.8% vs 0.9%, respectively, P = 1.0), and rates of all-cause death, re-MI,
and TVR. By multivariate analysis, old age, diabetes mellitus, renal dysfunction, and left ventricular dysfunction
were the independent predictors of MACE after BP-DES or 2G-DP-DES implantation.
Conclusions: BP-DES and 2G-DP-DES appear to have comparable 2-year safety and efficacy for the treatment of
AMI. However, longer-term follow-up is needed.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine
Citation
Seung-Ho Hur et al. (2016). Two-Year Safety and Efficacy of Biodegradable Polymer Drug-Eluting Stent Versus Second-Generation Durable Polymer Drug-Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR). Cardiology Clinics, 39(5), 276–284. doi: 10.1002/clc.22525
Type
Article
ISSN
0733-8651
DOI
10.1002/clc.22525
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33321
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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