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Two-Year Safety and Efficacy of Biodegradable Polymer Drug-Eluting Stent Versus Second-Generation Durable Polymer Drug-Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR).

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Author(s)
Seung-Ho HurIn-Cheol KimKi-Bum WonYun-Kyeong ChoHyuck-Jun YoonChang-Wook NamKwon-Bae KimMin-Seok KimJincheol ParkSeung-Woon RhaShung-Chull ChaeYoung-Jo KimChong-Jin KimMyeong-Chan ChoMyung-Ho JeongYoung-Keun AhnHyo-Soo KimTae-Hoon AhnKi-Bae SeungYangsoo JangJung-Han YoonIn-Whan SeongTaek-Jong HongJang-Ho BaeSeung-Jung Park
Keimyung Author(s)
Hur, Seung HoKim, In CheolCho, Yun KyeongYoon, Hyuck JunNam, Chang WookKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Cardiology Clinics
Issued Date
2016
Volume
39
Issue
5
Abstract
Background: Despite improved long-term safety of biodegradable polymer (BP) drug-eluting stents (DES)
compared to first-generation durable polymer (DP) DES, data on the safety and efficacy of BP-DES compared with
second-generation (2G) DP-DES in patients with acute myocardial infarction (AMI) are limited.
Hypothesis: To evaluate the safety and efficacy of BP-DES compared with 2G-DP-DES in the higher stent
thrombosis (ST) risk setting of AMI.
Methods: A total of 3359 AMI patients who received either BP-DES (n=261) or 2G-DP-DES (n=3098) were
included from the Korea Acute Myocardial Infarction Registry (KAMIR). Differences in baseline clinical and
angiographic characteristics were adjusted using a 1:5 propensity score matching analysis (n=261 for BP-DES
and n=1305 for 2G-DP-DES). The primary outcome was the incidence of major adverse cardiac events (MACE)
including all-cause death, recurrent myocardial infarction (re-MI), and target vessel revascularization (TVR). The
rate of definite or probable ST was also investigated.
Results: In adjusted analysis, there was no significant difference between the 2 groups in baseline clinical
and angiographic characteristics; 2-year MACE (10.7% and 9.9% in the BP-DES group and 2G-DP-DES group,
respectively, P = 0.679); ST incidence (0.8% vs 0.9%, respectively, P = 1.0), and rates of all-cause death, re-MI,
and TVR. By multivariate analysis, old age, diabetes mellitus, renal dysfunction, and left ventricular dysfunction
were the independent predictors of MACE after BP-DES or 2G-DP-DES implantation.
Conclusions: BP-DES and 2G-DP-DES appear to have comparable 2-year safety and efficacy for the treatment of
AMI. However, longer-term follow-up is needed.
Keimyung Author(s)(Kor)
허승호
김인철
조윤경
윤혁준
남창욱
김권배
Publisher
School of Medicine
Citation
Seung-Ho Hur et al. (2016). Two-Year Safety and Efficacy of Biodegradable Polymer Drug-Eluting Stent Versus Second-Generation Durable Polymer Drug-Eluting Stent in Patients With Acute Myocardial Infarction: Data from the Korea Acute Myocardial Infarction Registry (KAMIR). Cardiology Clinics, 39(5), 276–284. doi: 10.1002/clc.22525
Type
Article
ISSN
0733-8651
Source
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1002/clc.22525
DOI
10.1002/clc.22525
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33321
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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