The prostatic urethral angle can predict the response to alpha adrenoceptor antagonist monotherapy for treating nocturia in men with lower urinary tract symptom: A multicenter study

Authors
Byung Hoon KimKi Ho KimYoung Hwii KoPhil Hyun SongTae-Hwan KimBum Soo Kim
Department
Dept. of Urology (비뇨의학)
Issue Date
2016
Citation
Applications in Plant Sciences., Vol.4(1) : 30-35, 2016
ISSN
2168-0450
Abstract
Background: We evaluated ultrasonography variables associated with the improvement of nocturia after administration of alpha adrenoceptor antagonist (alpha blocker) monotherapy. Methods: From February to October 2014, 679 men with lower urinary tract symptoms (LUTS) underwent ultrasonography including prostate volume, transitional zone volume, prostatic urethral length, the ratio between prostatic urethral length and prostate volume (RPUL), intravesical prostatic protrusion (IPP), and prostatic urethral angle (PUA). Among them, 108 men who had pre-treatment nocturia without nocturnal polyuria (nocturnal polyuria index < 33%) and were treated with alpha blocker monotherapy over 3 months were enrolled. Patients were divided into the improved (< 2 times of nocturia) and non-improved group (more than 2 times) after administration of alpha blockers. Along with ultrasonography, international prostate symptom score (IPSS) and uroflowmetry was assessed. Results: After alpha blocker treatment, 25.0% of patients (27/108) showed improvement of nocturia. These patients were significantly younger (59.6 vs 68.0 years, P ¼ < 0.001) with lower PUA (31.8 vs. 39.4 , P ¼ 0.009) compared with the non-improved group. In ROC analysis, the area under the curve using the PUA was 0.653 (95% CI ¼ 0.532e0.774, P ¼ 0.018). Using 33.5 as a cut-off level, the sensitivity and specificity for predicting the improvement of nocturia after medication reached 67.9% and 55.6%, respectively. Patients with lower PUA (PUA < 33.5 ) had more improvement of nocturia (36.6 vs. 17.9%, P ¼ 0.030), lower IPSS score (14.2 vs. 18.3, P ¼ 0.005), and better quality of life index (3.1 vs 3.8, P ¼ 0.021). Conclusions: In the patients with lower PUA (particularly lower than 33.5 ), nocturia was improved by administration of alpha blocker monotherapy.
Keywords
Adrenergic alpha-antagonistsBenign prostatic hyperplasiaNocturiaProstate
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33392
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
Keimyung Author(s)
김병훈
File in this Item
oak-2016-0253.pdf(595.52 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE