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The prostatic urethral angle can predict the response to alpha adrenoceptor antagonist monotherapy for treating nocturia in men with lower urinary tract symptom: A multicenter study

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Author(s)
Byung Hoon KimKi Ho KimYoung Hwii KoPhil Hyun SongTae-Hwan KimBum Soo Kim
Keimyung Author(s)
Kim, Byung Hoon
Department
Dept. of Urology (비뇨의학)
Journal Title
Applications in Plant Sciences.
Issued Date
2016
Volume
4
Issue
1
Keyword
Adrenergic alpha-antagonistsBenign prostatic hyperplasiaNocturiaProstate
Abstract
Background: We evaluated ultrasonography variables associated with the improvement of nocturia
after administration of alpha adrenoceptor antagonist (alpha blocker) monotherapy.
Methods: From February to October 2014, 679 men with lower urinary tract symptoms (LUTS) underwent
ultrasonography including prostate volume, transitional zone volume, prostatic urethral
length, the ratio between prostatic urethral length and prostate volume (RPUL), intravesical prostatic
protrusion (IPP), and prostatic urethral angle (PUA). Among them, 108 men who had pre-treatment
nocturia without nocturnal polyuria (nocturnal polyuria index < 33%) and were treated with alpha
blocker monotherapy over 3 months were enrolled. Patients were divided into the improved (< 2
times of nocturia) and non-improved group (more than 2 times) after administration of alpha blockers.
Along with ultrasonography, international prostate symptom score (IPSS) and uroflowmetry was
assessed.
Results: After alpha blocker treatment, 25.0% of patients (27/108) showed improvement of nocturia.
These patients were significantly younger (59.6 vs 68.0 years, P ¼ < 0.001) with lower PUA (31.8 vs. 39.4 ,
P ¼ 0.009) compared with the non-improved group. In ROC analysis, the area under the curve using the
PUA was 0.653 (95% CI ¼ 0.532e0.774, P ¼ 0.018). Using 33.5 as a cut-off level, the sensitivity and
specificity for predicting the improvement of nocturia after medication reached 67.9% and 55.6%,
respectively. Patients with lower PUA (PUA < 33.5 ) had more improvement of nocturia (36.6 vs. 17.9%,
P ¼ 0.030), lower IPSS score (14.2 vs. 18.3, P ¼ 0.005), and better quality of life index (3.1 vs 3.8,
P ¼ 0.021).
Conclusions: In the patients with lower PUA (particularly lower than 33.5 ), nocturia was improved by
administration of alpha blocker monotherapy.
Keimyung Author(s)(Kor)
김병훈
Publisher
School of Medicine
Citation
Byung Hoon Kim et al. (2016). The prostatic urethral angle can predict the response to alpha adrenoceptor antagonist monotherapy for treating nocturia in men with lower urinary tract symptom: A multicenter study. Applications in Plant Sciences., 4(1), 30–35. doi: 10.1016/j.prnil.2015.12.002
Type
Article
ISSN
2168-0450
DOI
10.1016/j.prnil.2015.12.002
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33392
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Urology (비뇨의학)
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