Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas

Eun-Ik SonIl-Man KimDong-Won KimMan Bin YimYu-Na KangSang-Sook LeeKun-Young KwonSeong-Il SuhTaeg-Kyu KwonJung-Jeung LeeDong-Sug KimSang-Pyo Kim
Dept. of Neurosurgery (신경외과학); Dept. of Pathology (병리학); Dept. of Microbiology (미생물학); Dept. of Immunology (면역학); Dept. of Preventive Medicine (예방의학); Institute for Medical Science (의과학연구소)
Issue Date
Pathology International, Vol.53(2) : 67-73, 2003
Medulloblastomas occurring in children represent a histological spectrum of varying anaplasia and nodularity. In order to determine whether immunohistochemical markers might be useful parameters in subclassifying these tumors, 17 pediatric medulloblastomas, including nine diffuse/non-anaplastic, four diffuse/anaplastic, three nodular/non-anaplastic and one nodular/anaplastic subtypes, were studied. In the present report, we investigate the expression of neural cell adhesion molecule (NCAM), nerve growth factor receptor (NGFR), neurofilament (NF), synaptophysin (SYN), glial fibrillary acidic protein (GFAP), S100, Bcl-2, and Ki-67 by using the immunohistochemistry against specific antibodies. This study showed that NGFR, NF, GFAP and S100 were not detected in anaplastic subtypes of medulloblastomas (0/5), while non-anaplastic subtypes were mainly expressed within the nodules. All 17 tumors were reactive for NCAM, SYN and Bcl-2. In addition, Ki-67 labeling indices for anaplastic subtypes (39.0 +/- 7.42%) were significantly higher than that of non-anaplastic medulloblastomas (11.4 +/- 8.04%; P < 0.0001). These results suggest that immunohistochemical markers are a useful adjunct in characterizing subtypes of pediatric medulloblastomas. Key words: anaplasia, histopathology, immunohistochemistry, medulloblastoma, pediatric, subtype.
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
Keimyung Author(s)
손은익; 김엘; 김동원; 임만빈; 강유나; 이상숙; 권건영; 김상표; 서성일; 권택규; 이중정
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