Chemesthesis from volatile organic compounds: Psychophysical and neural responses

Authors
William S. CainNam-Soo LeePaul M. WiseRoland SchmidtByung-Hoon AhnJ. Enrique Cometto-MuñizMichael H. Abraham
Department
Dept. of Otorhinolaryngology (이비인후과학)
Issue Date
2006
Citation
Physiology Behavior, Vol.88(Issues 4–5) : 317-324, 2006
ISSN
0031-9384
Abstract
In Experiment 1, subjects sought to localize the nostril stimulated, left or right, in tests with nine esters (acetates, propionates, and butyrates) at concentrations meant to trigger chemesthesis (pungency, irritation). The task produced psychometric functions for chemesthetic detection unconfounded by olfactory sensations. The functions indicated a sharp transition from no detection to perfect detection, rather uniform across the esters, which themselves varied in potency by two log units. The correlation between the thresholds for the eight materials that yielded thresholds and predictions from a published linear free energy relationship (LFER) equaled 0.99. In Experiment 2, amplitude of the negative mucosal potential (NMP) was recorded from the septum. The resulting functions also increased with concentration sharply. Against a criterion amplitude of the NMP, thresholds measured in the first experiment (and predictions from the LFER) correlated 0.99. The NMP seems to offer an adequate objective measure of sensory irritation. The LFER, although effective predictively, could stand to have a parameter to anticipate that molecules beyond a certain size fail to trigger irritation. In the present case, a cut-off of chemesthetic potency occurred between butyl butyrate and hexyl butyrate for the group of subjects, with some variation of the boundary among individuals. Keywords Irritation; Chemical senses; Chemesthesis; Psychophysics; Neurophysiology; Negative mucosal potential; Linear free energy relationship
Keywords
IrritationChemical sensesChemesthesisPsychophysicsNeurophysiologyNegative mucosal potentialLinear free energy relationship
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33668
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
Keimyung Author(s)
안병훈
Full Text
https://www.sciencedirect.com/science/article/pii/S0031938406002216?via%3Dihub
File in this Item
 사서에게 요청하기
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE