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Chemesthesis from volatile organic compounds: Psychophysical and neural responses

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Author(s)
William S. CainNam-Soo LeePaul M. WiseRoland SchmidtByung-Hoon AhnJ. Enrique Cometto-MuñizMichael H. Abraham
Keimyung Author(s)
Ahn, Byung Hoon
Department
Dept. of Otorhinolaryngology (이비인후과학)
Journal Title
Physiology Behavior
Issued Date
2006
Volume
88
Issue
Issues 4–5
Keyword
IrritationChemical sensesChemesthesisPsychophysicsNeurophysiologyNegative mucosal potentialLinear free energy relationship
Abstract
In Experiment 1, subjects sought to localize the nostril stimulated, left or right, in tests with nine esters (acetates, propionates, and butyrates) at concentrations meant to trigger chemesthesis (pungency, irritation). The task produced psychometric functions for chemesthetic detection unconfounded by olfactory sensations. The functions indicated a sharp transition from no detection to perfect detection, rather uniform across the esters, which themselves varied in potency by two log units. The correlation between the thresholds for the eight materials that yielded thresholds and predictions from a published linear free energy relationship (LFER) equaled 0.99. In Experiment 2, amplitude of the negative mucosal potential (NMP) was recorded from the septum. The resulting functions also increased with concentration sharply. Against a criterion amplitude of the NMP, thresholds measured in the first experiment (and predictions from the LFER) correlated 0.99. The NMP seems to offer an adequate objective measure of sensory irritation. The LFER, although effective predictively, could stand to have a parameter to anticipate that molecules beyond a certain size fail to trigger irritation. In the present case, a cut-off of chemesthetic potency occurred between butyl butyrate and hexyl butyrate for the group of subjects, with some variation of the boundary among individuals.

Keywords
Irritation;
Chemical senses;
Chemesthesis;
Psychophysics;
Neurophysiology;
Negative mucosal potential;
Linear free energy relationship
Keimyung Author(s)(Kor)
안병훈
Publisher
School of Medicine
Citation
William S. Cain et al. (2006). Chemesthesis from volatile organic compounds: Psychophysical and neural responses. Physiology Behavior, 88(Issues 4–5), 317–324. doi: 10.1016/j.physbeh.2006.03.035
Type
Article
ISSN
0031-9384
Source
https://www.sciencedirect.com/science/article/pii/S0031938406002216?via%3Dihub
DOI
10.1016/j.physbeh.2006.03.035
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33668
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
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