계명대학교 의학도서관 Repository

The Effect of Radiographic Contrast Media on Reperfusion Injury in the Isolated Rat Heart

Metadata Downloads
Author(s)
Soo Yong LeeYoung Ho JangMi Young LeeJongmin HwangSang Hyun LeeMin Ku ChonSun Ae HwangJeong Su KimYong Hyun ParkKook Jin ChunJune Hong Kim
Publication Year
2014
Keyword
Contrast mediaHeartMyocardial infarctionMyocardial reperfusion
Abstract
Background and Objectives:

We investigated the effects of commonly used contrast media (CM) on myocardial ischemia-reperfusion injury in isolated rat hearts.


Subjects and Methods:

Isolated rat hearts were subjected to 30 minutes of regional ischemia and 2 hours of reperfusion. The following CM (1 mL/1 L Krebs-Henseleit buffer) were randomly perfused for 15 minutes beginning 5 minutes before reperfusion and ending 10 minutes after reperfusion: iohexol (n=8), iopromide (n=8), ioversol (n=8), iomeprol (n=8), iopamidol (n=7), ioxaglate (n=8), and iodixanol (n=7). The effects of a direct bolus injection of undiluted iohexol, iopromide, or ioxaglate (each n=6) via the aortic root immediately prior to reperfusion were also evaluated. The area of necrosis, expressed as the percentage of the area at risk (AN/AR), and cardiodynamic variables were measured.


Results:

The AN/AR of the control and experimental groups in the order described in methods was 33.7±6.4%, 30.3±7.4%, 34.7±12.6%, 29.2±10.2%, 20.9±7.6%, 22.6±8.7%, 18.8±7.9%, and 19.9±11.4%, respectively. Groups that received iomeprol and ioxaglate exhibited significantly decreased AN/AR values compared to those of control hearts (p=0.042 and p=0.013). No significant differences in the AN/AR were observed between control hearts and the groups injected with a single bolus of CM. No significant hemodynamic changes were noted after reperfusion among the groups.


Conclusion:

The overall effects of the CM on coronary reperfusion were not deleterious, and better effects were noted in two CM groups. However, it is unclear whether this result was attributed to a specific physiochemical property of the CM.
Department
Dept. of Preventive Medicine (예방의학)
Publisher
School of Medicine
Citation
Korean Circulation Journal, Vol.44(6) : 423-428, 2014
Type
Article
ISSN
1738-5520
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33773
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.