The Clinical Characteristics of Colonic Pseudo-obstruction and the Factors Associated with Medical Treatment Response: A Study Based on a Multicenter Database in Korea
- Affiliated Author(s)
- 박경식
- Alternative Author(s)
- Park, Kyung Sik
- Journal Title
- Journal of Korean Medical Science
- ISSN
- 1011-8934
- Issued Date
- 2014
- Keyword
- Colonic Pseudo-obstruction; Abdominal Distension; Colonic Dilatation; Transition Zone
- Abstract
- Colonic pseudo-obstruction (CPO) is defined as marked colonic distension in the absence of
mechanical obstruction. We aimed to investigate the clinical characteristics of CPO and the
factors associated with the response to medical treatment by using a multicenter database
in Korea. CPO was diagnosed as colonic dilatation without mechanical obstruction by using
radiologic and/or endoscopic examinations. Acute CPO occurring in the postoperative
period in surgical patients or as a response to an acute illness was excluded. CPO cases
were identified in 15 tertiary referral hospitals between 2000 and 2011. The patients’ data
were retrospectively reviewed and analyzed. In total, 104 patients (53 men; mean age at
diagnosis, 47 yr) were identified. Seventy-seven of 104 patients (74%) showed a transition
zone on abdominal computed tomography. Sixty of 104 patients (58%) showed poor
responses to medical treatment and underwent surgery at the mean follow-up of 7.4
months (0.5-61 months). Younger age at the time of diagnosis, abdominal distension as a
chief complaint, and greater cecal diameter were independently associated with the poor
responses to medical treatment. These may be risk factors for a poor response to medical
treatment.
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