Nationwide Seroe pidemiology of Hepatitis B Virus Infection in South Korea in 2009 Emphasizes the Coexistence of HBsAg and Anti-HBs

Authors
Byung Seok LeeYong Kyun ChoSook-Hyang JeongJoon Hyeok LeeDon LeeNeung Hwa ParkMoran KiKorean Hepatitis Epidemiology Study Group
Department
Dept. of Internal Medicine (내과학)
Issue Date
2013
Citation
Journal of Medical Virology, Vol.85(8) : 1327-1333, 2013
ISSN
0146-6615
Abstract
Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated the seroprevalence of HBV infection with an emphasis on the coexistence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In all, 290,212 people undergoing health check-up examinations in 29 institutions during 2009 were recruited. The crude seroprevalences of HBsAg and anti-HBs was adjusted by age, sex, and geographic area using the 2009 estimated population of Korea. The adjusted seroprevalences of HBsAg and anti-HBs was 4.0% and 73.5%, respectively. Males showed higher HBsAg positivity and lower anti-HBs positivity than females (P < 0.001). HBsAg positivity increased with age from 3.5% in people 20–29 years old to 4.8% in people 40–49 years old, followed by a decrease in people 50 years old. HBsAg positivity in Southern provinces (4.5%) including Jeju (5.9%), was significantly higher than that in Central provinces (3.6%; P < 0.001). Interestingly, HBsAg and anti-HBs coexisted in 0.1% of the total subjects and in 2.9% of the HBsAg-positive group, showing distinct age distribution and higher alanine aminotransferase levels than those of the group positive for only HBsAg. In conclusion, the seroprevalence of HBsAg and anti-HBs in Korea varies significantly by age, sex and geographical location and coexisted in 2.9% of HBsAg-positive subjects. Continuous monitoring of seroepidemiology may facilitate the eventual eradication of HBV infection.
Keywords
hepatitis B virusepidemiologyvaccinationseroprevalenceKorea
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33829
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
정우진
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.23594
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