계명대학교 의학도서관 Repository

Nationwide Seroe pidemiology of Hepatitis B Virus Infection in South Korea in 2009 Emphasizes the Coexistence of HBsAg and Anti-HBs

Metadata Downloads
Author(s)
Byung Seok LeeYong Kyun ChoSook-Hyang JeongJoon Hyeok LeeDon LeeNeung Hwa ParkMoran KiKorean Hepatitis Epidemiology Study Group
Keimyung Author(s)
Chung, Woo Jin
Department
Dept. of Internal Medicine (내과학)
Journal Title
Journal of Medical Virology
Issued Date
2013
Volume
85
Issue
8
Keyword
hepatitis B virusepidemiologyvaccinationseroprevalenceKorea
Abstract
Hepatitis B virus (HBV) infection is the major cause of chronic liver disease in Korea. This study investigated the seroprevalence of HBV infection with an emphasis on the coexistence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs). In all, 290,212 people undergoing health check-up examinations in 29 institutions during 2009 were recruited. The crude seroprevalences of HBsAg and anti-HBs was adjusted by age, sex, and geographic area using the 2009 estimated population of Korea. The adjusted seroprevalences of HBsAg and anti-HBs was 4.0% and 73.5%, respectively. Males showed higher HBsAg positivity and lower anti-HBs positivity than females (P < 0.001). HBsAg positivity increased with age from 3.5% in people 20–29 years old to 4.8% in people 40–49 years old, followed by a decrease in people 50 years old. HBsAg positivity in Southern provinces (4.5%) including Jeju (5.9%), was significantly higher than that in Central provinces (3.6%; P < 0.001). Interestingly, HBsAg and anti-HBs coexisted in 0.1% of the total subjects and in 2.9% of the HBsAg-positive group, showing distinct age distribution and higher alanine aminotransferase levels than those of the group positive for only HBsAg. In conclusion, the seroprevalence of HBsAg and anti-HBs in Korea varies significantly by age, sex and geographical location and coexisted in 2.9% of HBsAg-positive subjects. Continuous monitoring of seroepidemiology may facilitate the eventual eradication of HBV infection.
Keimyung Author(s)(Kor)
정우진
Publisher
School of Medicine
Citation
Byung Seok Lee et al. (2013). Nationwide Seroe pidemiology of Hepatitis B Virus Infection in South Korea in 2009 Emphasizes the Coexistence of HBsAg and Anti-HBs. Journal of Medical Virology, 85(8), 1327–1333. doi: 10.1002/jmv.23594
Type
Article
ISSN
0146-6615
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.23594
DOI
10.1002/jmv.23594
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/33829
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.