Effects of Berberine on Hippocampal Neuronal Damage and Matrix Metalloproteinase-9 Activity Following Transient Global Cerebral Ischemia

Authors
Jong-Wook ParkSeong-Ryong LeeJeong-Seok HongYeun-Kyung ChuHyung LeeByung-Hoon AhnJae-Hyung ParkMi-Jung KimSunghye LeeHo-Sang RyooJung-Hee Jang
Department
Dept. of Pharmacology (약리학); Brain Research Institute (뇌연구소); Dept. of Neurology (신경과학); Dept. of Otorhinolaryngology (이비인후과학); Dept. of Physiology (생리학); Dept. of Immunology (면역학)
Issue Date
2012
Citation
Journal of Neuroscience Research, Vol.90(2) : 489-497, 2012
ISSN
0360-4012
Abstract
Berberine, an isoquinoline alkaloid with a long history oBerberine, an isoquinoline alkaloid with a long history of use in Chinese medicine, has several important pharmacological effects. Several studies have revealed that berberine has neuroprotective and neuropsychiatric effects. However, there are few reports regarding the protective effect of berberine against neuronal damage following transient global cerebral ischemia. In this study, mice were subjected to 20 min of global brain ischemia and sacrificed 72 hr later. Berberine was administered for 7 days prior to ischemia and daily until sacrifice. Mice treated with berberine showed reduced matrix metalloproteinase-9 (MMP-9) activity. Berberine inhibited gelatinase activity directly in in situ zymography and reduced neuronal damage following global ischemia. Laminin expression and NeuN expression were markedly reduced in CA1 and CA2 areas after ischemia, and berberine reduced the laminin degradation and neuronal loss. In the TUNEL assay, damaged neurons were also apparent in the CA1 and CA2 areas, and berberine reduced TUNEL-positive cells. These data demonstrate that berberine, a plant alkaloid, may protect from hippocampal neuronal damage following transient global ischemia by reducing MMP-9 activity.
Keywords
berberineglobal brain ischemiamatrix metalloproteinaseneuroprotection
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33843
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Keimyung Author(s)
이형; 안병훈; 박재형; 이성용; 박종욱; 장정희
Full Text
http://lps3.onlinelibrary.wiley.com.proxy.dsmc.or.kr/doi/abs/10.1002/jnr.22756
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