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Effects of Berberine on Hippocampal Neuronal Damage and Matrix Metalloproteinase-9 Activity Following Transient Global Cerebral Ischemia

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Affiliated Author(s)
이형안병훈박재형이성용박종욱장정희
Alternative Author(s)
Lee, HyungAhn, Byung HoonPark, Jae HyungLee, Seong RyongPark, Jong WookJang, Jung Hee
Journal Title
Journal of Neuroscience Research
ISSN
0360-4012
Issued Date
2012
Keyword
berberineglobal brain ischemiamatrix metalloproteinaseneuroprotection
Abstract
Berberine, an isoquinoline alkaloid with a long history oBerberine, an isoquinoline alkaloid with a long history of
use in Chinese medicine, has several important pharmacological
effects. Several studies have revealed that
berberine has neuroprotective and neuropsychiatric
effects. However, there are few reports regarding the
protective effect of berberine against neuronal damage
following transient global cerebral ischemia. In this study,
mice were subjected to 20 min of global brain ischemia
and sacrificed 72 hr later. Berberine was administered
for 7 days prior to ischemia and daily until sacrifice.
Mice treated with berberine showed reduced matrix
metalloproteinase-9 (MMP-9) activity. Berberine inhibited
gelatinase activity directly in in situ zymography and
reduced neuronal damage following global ischemia.
Laminin expression and NeuN expression were markedly
reduced in CA1 and CA2 areas after ischemia, and
berberine reduced the laminin degradation and neuronal
loss. In the TUNEL assay, damaged neurons were also
apparent in the CA1 and CA2 areas, and berberine
reduced TUNEL-positive cells. These data demonstrate that
berberine, a plant alkaloid, may protect from hippocampal
neuronal damage following transient global ischemia by
reducing MMP-9 activity.
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