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Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder

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Author(s)
조철현송광순민병우배기철이경재하은영황일선
Alternative Author(s)
Cho, Chul HyunSong, Kwang SoonMin, Byung WooBae, Ki CheorLee, Kyung JaeHa, Eun YoungHwang, Il Seon
Publication Year
2013
Keyword
Frozen shoulderjoint capsulesubacromial bursacytokinesinflammationfibrosis
Abstract
Background:
Frozen shoulder is a debilitating condition characterized by gradual loss of glenohumeral motion with chronic inflammation and capsular fibrosis. Yet its pathogenesis remains largely unknown. We hypothesized that the subacromial bursa may be responsible for the pathogenesis of frozen shoulder by producing inflammatory cytokines.


Materials and methods:

We obtained joint capsules and subacromial bursae from 14 patients with idiopathic frozen shoulder and from 7 control subjects to determine the expression levels of interleukin (IL) 1α, IL-1β, IL-6, tumor necrosis factor α (TNF-α), cyclooxygenase (COX) 1, and COX-2 by real-time reverse transcriptase–polymerase chain reaction, immunohistochemistry, and enzyme-linked immunosorbent assay.


Results:

IL-1α, IL-1β, TNF-α, COX-1, and COX-2 were expressed at significantly high levels in the joint capsules of the frozen shoulder group compared with those of the control group. Intriguingly, IL-1α, TNF-α, and COX-2 were also expressed at significantly high levels in the subacromial bursae of the frozen shoulder group compared with those of the control group. Immunohistochemical analysis showed increased expression of COX-2 in both the joint capsules and subacromial bursae of the frozen shoulder group.


Conclusions:

These findings imply that elevated levels of inflammatory cytokines in the subacromial bursa may be associated with the pathogenesis of inflammation evolving into fibrosis.
Department
Dept. of Biochemistry (생화학)
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Pathology (병리학)
Publisher
School of Medicine
Citation
Journal of Shoulder and Elbow Surgery, Vol.22(5) : 666-672, 2013
Type
Article
ISSN
1058-2746
DOI
10.1016/j.jse.2012.06.014
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/33885
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